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Chronic Migraine

Chronic migraine (15+ headache days/month) is a disabling neurological disease affecting millions of Americans. A new class of CGRP-targeting medications — monthly injections and daily pills — has revolutionized prevention, offering 50%+ reduction in migraine days for many patients.

📊 Chronic migraine affects ~3–4 million Americans. Migraine is the 2nd leading cause of disability worldwide. Women are 3× more likely to develop migraine than men. The average chronic migraine patient loses multiple workdays per month.
chronic migraine CGRP migraine Aimovig Ajovy Emgality Nurtec
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👥 ~3-4 million in US (chronic); 39 million total with migraine · Patients in US
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🏥 Neurology / Headache Medicine · Specialty
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💊 5 available · FDA-approved drugs

FDA-Approved Treatments

Current approved therapies — what they are, who makes them, and what to ask your doctor.

Aimovig
erenumab · Amgen / Novartis
CGRP Receptor Monoclonal Antibody (injection)

The first CGRP-targeting migraine prevention drug, FDA-approved in 2018. Blocks the CGRP receptor, preventing migraine attacks. Clinical trials showed 50% reduction in monthly migraine days in ~40–45% of patients. The Aimovig Ally Support Program provides co-pay assistance — most commercially insured patients pay $0/month.

💰 ~$700/month list price Monthly subcutaneous auto-injector (self-administered) ✓ Patient Assist
Ajovy
fremanezumab · Teva
CGRP Monoclonal Antibody (injection)

FDA-approved in 2018. Available as monthly or quarterly injection — the quarterly option (3 doses at once every 3 months) is popular for patients who prefer fewer injection days. Teva co-pay assistance program available for commercially insured patients.

💰 ~$700/month list price Monthly or quarterly subcutaneous injection ✓ Patient Assist
Emgality
galcanezumab · Eli Lilly
CGRP Monoclonal Antibody (injection)

FDA-approved in 2018. Also approved for episodic cluster headache — the only CGRP antibody with this dual indication. Monthly self-injection. Lilly Cares Foundation provides patient assistance.

💰 ~$700/month list price Monthly subcutaneous auto-injector (self-administered) ✓ Patient Assist
Nurtec ODT
rimegepant · Pfizer
CGRP Antagonist — gepant (oral dissolving tablet)

The first medication approved for both acute treatment AND prevention of migraine. Dissolves under the tongue — no injection needed. Pfizer Access 360 program provides co-pay assistance.

💰 ~$900/month list price Oral disintegrating tablet — acute OR every other day for prevention ✓ Patient Assist
Botox
onabotulinumtoxinA · AbbVie
Neurotoxin — preventive injections

FDA-approved for chronic migraine prevention in 2010. Injections around head and neck every 12 weeks reduce migraine frequency. ~50% reduction in headache days in clinical trials. AbbVie My Botox Now program provides co-pay assistance. Medicare generally covers Botox for chronic migraine.

💰 ~$1,200–1,500/treatment; every 3 months 31–39 injections around head and neck every 12 weeks (in-office) ✓ Patient Assist

Community Feed

What patients and caregivers are saying about Chronic Migraine

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📋 Newly Diagnosed Guide

Newly diagnosed with chronic migraine? Here's what to do first.

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1. See a headache specialist

Headache medicine is a subspecialty within neurology. A headache specialist knows all current treatment options and has experience with prior authorization for CGRP medications. The American Headache Society (americanheadachesociety.org) has a specialist finder.

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2. Start a headache diary immediately

You need to document headache days to qualify for Botox or CGRP antibodies. Migraine Buddy (free app) is the most comprehensive. Track: date, duration, intensity, medications taken, and possible triggers.

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3. Get a preventive medication — not just triptans

With chronic migraine, you need preventive medication. Acute-only treatment leads to medication-overuse headache. Start with generics (topiramate, amitriptyline, propranolol) or ask about CGRP antibodies if you've failed older preventives.

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4. CGRP drugs are $700/month — but most patients pay $0

Apply through the manufacturer's co-pay program: Aimovig Ally Support, Teva's Ajovy program, Lilly Cares for Emgality, Pfizer Access 360 for Nurtec. All bring monthly cost to $0 for commercially insured patients.

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5. Non-drug interventions help too

Consistent sleep schedule, regular meals, hydration, aerobic exercise, and magnesium supplementation (400mg/day) all have evidence for migraine reduction. Biofeedback and CBT have clinical evidence. These complement medications but don't replace preventive therapy for chronic migraine.

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Frequently Asked Questions

Real questions from patients and caregivers — answered in plain English.