FDA-Approved Treatments
Current approved therapies — what they are, who makes them, and what to ask your doctor.
The first CGRP-targeting migraine prevention drug, FDA-approved in 2018. Blocks the CGRP receptor, preventing migraine attacks. Clinical trials showed 50% reduction in monthly migraine days in ~40–45% of patients. The Aimovig Ally Support Program provides co-pay assistance — most commercially insured patients pay $0/month.
FDA-approved in 2018. Available as monthly or quarterly injection — the quarterly option (3 doses at once every 3 months) is popular for patients who prefer fewer injection days. Teva co-pay assistance program available for commercially insured patients.
FDA-approved in 2018. Also approved for episodic cluster headache — the only CGRP antibody with this dual indication. Monthly self-injection. Lilly Cares Foundation provides patient assistance.
The first medication approved for both acute treatment AND prevention of migraine. Dissolves under the tongue — no injection needed. Pfizer Access 360 program provides co-pay assistance.
FDA-approved for chronic migraine prevention in 2010. Injections around head and neck every 12 weeks reduce migraine frequency. ~50% reduction in headache days in clinical trials. AbbVie My Botox Now program provides co-pay assistance. Medicare generally covers Botox for chronic migraine.
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Go to Pulse →Newly diagnosed with chronic migraine? Here's what to do first.
Headache medicine is a subspecialty within neurology. A headache specialist knows all current treatment options and has experience with prior authorization for CGRP medications. The American Headache Society (americanheadachesociety.org) has a specialist finder.
You need to document headache days to qualify for Botox or CGRP antibodies. Migraine Buddy (free app) is the most comprehensive. Track: date, duration, intensity, medications taken, and possible triggers.
With chronic migraine, you need preventive medication. Acute-only treatment leads to medication-overuse headache. Start with generics (topiramate, amitriptyline, propranolol) or ask about CGRP antibodies if you've failed older preventives.
Apply through the manufacturer's co-pay program: Aimovig Ally Support, Teva's Ajovy program, Lilly Cares for Emgality, Pfizer Access 360 for Nurtec. All bring monthly cost to $0 for commercially insured patients.
Consistent sleep schedule, regular meals, hydration, aerobic exercise, and magnesium supplementation (400mg/day) all have evidence for migraine reduction. Biofeedback and CBT have clinical evidence. These complement medications but don't replace preventive therapy for chronic migraine.
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Frequently Asked Questions
Real questions from patients and caregivers — answered in plain English.