Comedian and television star George Lopez was diagnosed with a genetic kidney disorder that caused his kidneys to function at only about 20% capacity. In April 2005, his mother — Ann Serrano, from whom he had been estranged — donated one of her kidneys to him in a living-donor transplant.
The story gained particular emotional weight because of the complicated relationship between Lopez and his mother. He had publicly discussed a difficult childhood and years of estrangement. The transplant represented a moment of profound reconciliation as well as a medical lifesaving event.
Lopez has spoken extensively about his kidney disease and transplant in interviews and in his stand-up comedy, bringing characteristic humor to a deeply serious subject. His openness has helped raise awareness of kidney disease — particularly in Latino communities, which face higher rates of kidney disease due to higher rates of diabetes and hypertension.
In 2011, Lopez and his then-wife Ann divorced. He has continued to manage his health and be an advocate for kidney health and organ donation.